Yes, in addition to the Master Record Selection rule DataGroomr allows to compare two datasets using cross-object dataset feature. Parent dataset is always a baseline for determining master record.
1. Create a dataset with a filter based on any combination of the fields (for example, Leads owned by VP)
2. Create cross-object dataset and select Parent: Leads owned by VP dataset, Child: all Leads dataset
Records from the Parent dataset will be master records and will be retained in Salesforce.